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Implications of oxidative stress in the pathogenesis and treatment of hyperpigmentation disorders

SEAMARK: Randomized phase 2 study of pembrolizumab + encorafenib + cetuximab vs pembrolizumab alone for first-line treatment of BRAF V600Emutant microsatellite instabilityhigh (MSI-H)/mismatch repair deficient (dMMR) metastatic colorectal cancer (CRC)

Patients are initially treated with a high loading dose, then a maintenance dose over several days

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Linden A, Hansson L, Andersson A, Palmqvist M, Arvidsson P, Lofdahl CG, Larsson P, Lotvall J